Agilent and Singapore's NATi Partner to Advance Lipid-Conjugated Oligonucleotide Research

Agilent Technologies Inc.  announced a two-year research collaboration agreement with Singapore's Nucleic Acid Therapeutics Initiative (NATi), hosted by Agency for Science, Technology and Research (A*STAR), to accelerate research into complex oligonucleotide (oligo) candidates, a promising frontier in precision therapeutics with potential applications across cardiovascular-metabolic, rare and infectious diseases.

Under this agreement, the collaboration will focus on developing end-to-end analytical and preparative workflows to support ligand-conjugated strategies, a new platform designed to extend oligo delivery beyond the liver tissues, unlock access to extrahepatic tissues and expand the therapeutic addressable market.

"Lipid-conjugated oligonucleotides represent a promising next frontier in nucleic acid therapeutics, particularly in expanding beyond hepatic delivery. Working with strategic partners like Agilent allows us to tighten the value chain from research to clinic, accelerating the development of next-generation oligo therapeutics that address areas of significant unmet medical need," said Dr Mohamed ElSayed, Executive Director of Nucleic Acid Therapeutics Initiative (NATi).    

"As oligo-based therapies continue to transform precision medicine, the ability to reliably analyze and purify complex conjugates becomes increasingly critical. Our priority remains to help existing and new biopharma customers accelerate new discoveries through research advancement. This collaboration is yet another example of our commitment to investing in high-growth markets while delivering on Agilent's mission of improving the quality of life," said Bharat Bhardwaj, Vice President of APAC Sales at Agilent.