Collaborate across project teams to establish in vivo strategy and study plans for drug discovery projects.
Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Supervise and guide a small team of scientists
Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
Ensure team members comply with all regulatory requirements and internal policies.
Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.
Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment.
Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.
Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.
Qualifications
Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development OR
MS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 10 years industry experience including technical and scientific experience in drug discovery and preclinical development OR
BS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum 13 years industry experience including technical and scientific experience in drug discovery and preclinical development
Experience in collaborative research in Oncology drug discovery programs.
Experience with animal models of human cancers
Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
Experience supervising a small team of Scientists
Excellent written and oral communication and presentation skills
Proficiency with all common office and scientific software
